ORABOON

ORABOON provides the WHO-recommended Oral Rehydration Solution (ORS) formula — the scientifically validated electrolyte-glucose combination that exploits the sodium-glucose co-transport (SGLT1) mechanism in the intestinal brush border to maximise water and electrolyte absorption during diarrhoeal illness.

The SGLT1 co-transporter on the luminal surface of enterocytes actively transports glucose and sodium together in a 1:1 ratio across the intestinal membrane — with each glucose molecule bringing one sodium ion (and by osmosis, water) into the enterocyte. Critically, this co-transport mechanism remains functional even in the presence of secretory diarrhoea caused by cholera toxin, enterotoxins, and rotavirus — which disrupt the separate sodium transport channels responsible for most intestinal sodium absorption but cannot block SGLT1.

The WHO low-osmolarity ORS formula (sodium 75 mEq/L, potassium 20 mEq/L, citrate 10 mEq/L, glucose 75 mmol/L, total osmolarity 245 mOsm/L) is specifically optimised to: maximise SGLT1-mediated water absorption, replace the exact electrolyte losses of diarrhoeal stool, avoid hypernatraemia from excessive sodium, and provide metabolic alkalinisation through citrate (which is metabolised to bicarbonate, correcting metabolic acidosis from diarrhoeal losses).

Potassium Chloride replaces potassium lost in diarrhoeal stool (a major clinical concern in prolonged diarrhoea, particularly in children, where hypokalaemia can cause life-threatening cardiac arrhythmias). Sodium Citrate corrects metabolic acidosis while providing alkalinisation of the urinary tract.

Acute Diarrhoeal Dehydration — All Ages (Primary, WHO-endorsed): ORS is the cornerstone of diarrhoea management globally — preventing dehydration-related mortality from gastroenteritis, traveller's diarrhoea, cholera, and other secretory diarrhoeas. WHO/UNICEF estimates ORS has saved over 50 million lives since its introduction.

Paediatric Acute Gastroenteritis: The primary preventive intervention for diarrhoeal dehydration in children — given alongside ondansetron (to stop vomiting) and zinc supplementation (GUTSUIT ZN) as the complete WHO-recommended triple therapy.

Cholera: ORS can replace 90–95% of fluid losses in cholera — enabling outpatient management of most cholera cases that would otherwise require hospitalisation for IV fluids.

Heat Stroke and Excessive Sweating: Electrolyte and water replacement following vigorous exercise, heat exposure, or fever-associated sweating.

Post-Surgical Fluid Restoration: Early oral fluid restoration following procedures where IV fluids have been used.

Vomiting and Fever: Small frequent sips of ORS maintain hydration during vomiting (in sips between episodes) and fever (replacing insensible fluid losses).

Dosage and administration should be as prescribed by a qualified doctor or medical professional. Do not self-medicate. Always follow your physician's instructions regarding dose, frequency and duration of treatment.