UTICUT

UTICUT is a triple-component nutraceutical syrup targeting urinary tract infection prevention and urological symptom management through three complementary non-antibiotic mechanisms.

Cranberry Extract (Proanthocyanidins — PACs): Cranberry's anti-UTI mechanism is now understood to be primarily mediated by type A proanthocyanidins (PACs) — a specific oligomeric form of proanthocyanidin found almost exclusively in cranberries. Type A PACs specifically inhibit the adhesion of uropathogenic E. coli (UPEC) — particularly those expressing type 1 and type P fimbriae — to urothelial cell surface receptors. Without fimbrial adhesion, UPEC cannot colonise the bladder wall and is flushed out during normal urination. This anti-adhesion mechanism works upstream of infection establishment, providing a non-antibiotic UTI prevention strategy that does not generate antibiotic resistance.

D-Mannose (2–3mg per 5mL): D-Mannose is a natural monosaccharide structurally related to glucose that is absorbed slowly from the gut and excreted almost entirely unchanged in urine. The mannose-binding type 1 fimbriae of uropathogenic E. coli bind to D-mannose on urothelial surface glycoproteins for colonisation — when high urinary D-mannose concentrations are present from supplementation, the fimbriae bind preferentially to free urinary D-mannose rather than to urothelial receptors, effectively saturating the adhesin binding sites and preventing bacterial attachment. D-mannose thus works as a competitive inhibitor of E. coli adhesion.

Potassium Magnesium Citrate: A urinary alkaliniser that raises urinary pH above 6.5 — the alkaline environment reduces uroepithelial irritation from acidic urine in dysuria, inhibits bacterial growth (E. coli prefers slightly acidic environments), and prevents the uric acid and calcium oxalate crystallisation responsible for renal stones. Citrate also directly inhibits calcium oxalate crystal nucleation and aggregation in urine.

UTICUT is indicated for recurrent UTI prevention, dysuria management, and urinary health support where non-antibiotic approaches are clinically appropriate.

Recurrent Urinary Tract Infections (Primary): Women with 3+ UTI episodes per year — cranberry PACs + D-mannose provide synergistic non-antibiotic UTI prophylaxis by targeting the fimbrial adhesion step that initiates all E. coli UTIs. Clinical trials show cranberry-D-mannose combinations reduce UTI recurrence by 40–60% in susceptible women.

Urinary Dysuria and Discomfort: Potassium magnesium citrate reduces the burning discomfort of acidic urine in active UTI and post-UTI sensitivity, providing rapid symptomatic relief alongside antibiotic treatment.

Renal Stone Prevention (Calcium Oxalate and Uric Acid): Citrate's crystal nucleation inhibition, combined with urinary alkalinisation, is evidence-based for preventing recurrence of calcium oxalate and uric acid renal stones.

Post-Antibiotic UTI Prophylaxis: Following antibiotic treatment of acute UTI, transitioning to D-mannose + cranberry for ongoing prevention avoids the antibiotic resistance implications of long-term antibiotic prophylaxis.

Catheter-Associated UTI Prevention: In patients with urinary catheters, D-mannose and cranberry PACs reduce E. coli biofilm formation on catheter surfaces — a specific and evidence-supported application.

Dosage and administration should be as prescribed by a qualified doctor or medical professional. Do not self-medicate. Always follow your physician's instructions regarding dose, frequency and duration of treatment.