BACTRUSH TZ

Ciprofloxacin (500mg) inhibits DNA gyrase and topoisomerase IV causing double-strand DNA breaks in aerobic gram-negative bacteria. Tinidazole (600mg) is a second-generation nitroimidazole generating reactive nitro radicals that cause lethal DNA strand breaks in anaerobes and protozoa — with a longer half-life (12–14 hours) than metronidazole enabling once or twice-daily dosing. The combination covers aerobic gram-negative organisms (ciprofloxacin) plus anaerobes, Giardia, Entamoeba, and Trichomonas (tinidazole). See BACTRUSH 500 and OFLOFT OZ for detailed mechanisms.

Mixed aerobic-anaerobic gastrointestinal infections: amoebic dysentery, Giardiasis, bacterial gastroenteritis, traveller's diarrhoea, intra-abdominal infections, dental and oro-facial abscesses with anaerobic involvement, pelvic inflammatory disease, and urogenital trichomoniasis. Tinidazole's coverage of Pseudomonas (partial, from ciprofloxacin) alongside anaerobic organisms makes this combination particularly valuable for Pseudomonas-prone settings.

Dosage and administration should be as prescribed by a qualified doctor or medical professional. Do not self-medicate. Always follow your physician's instructions regarding dose, frequency and duration of treatment.